低同源性蛋白质结构预测

基因组计划在实施产生了大量的DNA序列信息,如何有效地利用这些信息来研究基因的产物－蛋白质的结构与功能成为引入注目的研究领域,同源蛋白质结构预测及蛋白质折工识别是在基因组水平上进行蛋白质结构预测的有效方法,酵母基因组中约有50％的基因可以通过这类方法来确定其表面产物蛋白质的结构[1],但是目前所采用的方法在低同源性蛋白质的结构预测方面尚存在较大困难。     

Bivariant K-Theories for C*-Algebras

A new framework for bivariant K-theory is developed. Various types of homology-cohomology theories are discussed. Our techniques can be used for producing natural elements in E-theory out of continuous fields with non-isomorphic fibers. An alternative definition for the Kasparov product in E-theory is proposed.     

Analogue Between Dynamic Hamiltonian-Operators of a Mesoscopic Ring Carrying Persistent Current and a Josephson Junction

By making the analogy between the operator Hamiltonians of a mesoscopic ring carrying the persistent current and a Josephson junction we have introduced a phase operator and entangled state representation to establish a theoretical formalism for the ring system.     

Asymptotic Expansions for Closed Orbits in Homology Classes

In this paper, we study the behaviour of the counting function associated to the closed geodesics lying in a prescribed homology class on a compact negatively curved manifold. Our main result is an asymptotic expansion. We also obtain results in the wider context of periodic orbits of Anosov flows.     

谈谈与图有关的几种复形的同调群

我们从组合拓扑方法在图论的应用中,着重介绍与图有关的几种复形的近期研究动态,论述其中一些基础性的问题,并提出一些可供研究的新问题。     

Waldhausen范畴的陈映射

本文讨论了关于 Ｗａｌｄｈａｕｓｅｎ范畴的Ｋ理论与循环同调理论的联系．主要是推广了 Ｄｅｎｎｉｓ迹映射和Ｊｏｎｅｓ－Ｇｏｏｄｗｉｌｌｉｅ Ｃｈｅｒｎ映射．证明了迹映射保持各自的乘法结构．最后讨论了双变量的情形．     

Biocompatible Lipid‐Coated Persistent Luminescent Nanoparticles for In Vivo Imaging of Dendritic Cell Migration

Dendritic cell (DC)‐based vaccines for immunotherapy have already achieved promising results in the last decade. To further improve current treatment protocols and enhance the therapeutic outcome, noninvasive in vivo tracking of DCs remains of crucial importance. Persistent luminescent nanoparticles (PLNPs) are inorganic materials which show an afterglow for hours after the optical excitation has ceased. If the afterglow is in the near‐infrared, the emission of injected particles can be tracked in vivo. However, stability and toxicity issues limit the use of bare PLNPs for biological applications. Therefore, appropriate surface functionalization is needed to improve their biocompatibility. In this study, it is demonstrated that near‐infrared light emitting LiGa₅O₈:Cr³⁺ nanoparticles can be functionalized with a biocompatible lipid coating which provides them with outstanding stability in biological media. In vitro experiments show efficient uptake, absence of cytotoxicity even at very high particle concentrations, and no adverse effects on the maturation potential of DCs. DCs labeled with lipid‐coated LiGa₅O₈:Cr³⁺ nanoparticles injected in mice can be imaged over days, confirming efficient in vivo migration to the popliteal lymph node. Together the results show that lipid coated LiGa₅O₈:Cr³⁺ nanoparticles possess excellent possibilities for further use in research and development of DC based vaccines.     

Li5Zn8Ga5Ge9O36: Cr3+, Ti4+: A Long Persistent Phosphor Excited in a Wide Spectral Region from UV to Red Light for Reproducible Imaging through Biological Tissue

Near‐infrared (NIR) long‐persistent phosphors (LPPs) have emerged as a potential solution for bio‐imaging applications over the past few years. However, there are enormous challenges regarding their in situ application based on their dependence on short‐wavelength excitation. In this paper, we report a multi‐spectral excited NIR LPP, Li₅Zn₈Ga₅Ge₉O₃₆: 1.5 % Cr³⁺, 0.5 % Ti⁴⁺, which overcomes the limitations of functional processes in biological tissues and other complex systems. This LPP exhibits a high luminescent intensity and a long emission duration in the NIR region (700–800 nm). The applicability of this phosphor to tissue imaging is demonstrated experimentally. Its persistent luminescence (PersL) can easily penetrate approximately 2 mm of pork flesh. More importantly, this phosphor can be re‐charged in situ using a red LED or laser diode array to provide renewed NIR PersL for biological tissues, which is beneficial for long‐term biological tissue imaging applications with high signal‐to‐noise ratios. Systematic investigations of the nature of energy traps and PersL mechanisms are also reported in this paper.     

On Shifts along Trajectories

The extension of the theory of boundary-value problems to ordinary differential equations and inclusions with discontinuous right-hand sides based on the construction of a new version of the method of shifts along trajectories is continued.